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The pharmacological activities of paeoniflorin obtained from paeony roots, FM 100 from glycyrrhiza roots, crude saikosides from bupleurum roots, crude platycodin from platycodon roots, and both of ginsenoside Rb and ginsenoside Rg series from ginseng roots were investigated. Paeoniflorin, FM 100, crude saikosides, and crude platycodin exhibited sedative, antipyretic, anlagesic and anti-ulcerative actions. In addition, crude saidosides and crude platycodin showed antitussive and the potent anti-inflammatory action. An expectorant action was also observed with crude platycodin. These results coincided with the clinical applications of the aforementioned oriental medicinals, It also should be noted that crude saikosides and crude platycodin are preferable to the other steroidal and nonsteroidal drugs as an anti-inflammatory agent, because the drugs aggravate the digestive ulcer. In ginseng, G No.3 and GNS fractions out of ginsenoside Rb series showed CNS-depressant actions, whereas G No. 4 and ginsenoside Rg series showed stimulant and antifatigue actions. The synergistic effects identified between paeoniflorin and FM 100 on the various pharmacological activities, have verified the reasonability of combined uses of two oriental drugs as Jakyak Gamcho-Tang.
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